This study aims to evaluate the relationship between serum finasteride levels and PSA levels in patients with benign prostatic hyperplasia (BPH).
Study design:We conducted a single-center study using a randomized, single-blind, crossover, double-blind, placebo-controlled, randomized study design.
Study population:Patients diagnosed with BPH and patients taking finasteride for 1 week prior to a study visit.
Study methods:We included patients diagnosed with benign prostatic hyperplasia (BPH) as a secondary outcome. We included patients who underwent prostate biopsy within the first 4 weeks of follow-up, and excluded patients who were excluded due to the presence of contraindications to finasteride. We included patients with serum PSA (U/mL) >0.3 ng/mL. Patients who were not responding to finasteride, as defined by serum PSA >0.3 ng/mL, were excluded.
Results:A total of 4,837 patients were included in the finasteride-treated group and 1,976 in the placebo-treated group. The median age was 62 (range 21 to 94 years). The prevalence of benign prostatic hyperplasia was significantly lower in patients treated with finasteride compared to those in the placebo group (3.3% vs 5.9%, p<0.001). The prevalence of PSA (U/mL) was significantly higher in patients treated with finasteride compared to the placebo group (3.6% vs 1.6%, p<0.001). The incidence of BPH was significantly lower in patients receiving finasteride compared to patients receiving placebo (4.4% vs 6.7%, p<0.001).
Conclusions:The findings suggest that finasteride can improve serum PSA levels in patients with BPH.
Citation:Foucault, C, et al. (2020, April) Clinical Dosing of Finasteride in BPH. PLoS Med 4(3): e1009. https://doi.org/10.1371/journal.pmed.100909
Editor:Anna M. Venter, Fudan University of Science and Technology, Malaysia
Received:June 23, 2020;Accepted:July 15, 2020;Published:August 10, 2020
Copyright:© 2020�oude et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:This research was supported by grants from the National Institutes of Health (P01 AI15961 and P01 AI15962), the Bill and Melinda Gates Foundation (R01 AI092721), and the Canadian Institutes of Health Research (ICRR) to L. D. L. (J. J. C. K.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
Benign prostatic hyperplasia (BPH) is a type of enlarged prostate. BPH is often misdiagnosed as benign prostatic hyperplasia (BPH) by the urologic team. The prevalence of BPH is increasing because of the aging population. While the diagnosis of BPH has been made in older men, the prevalence of BPH is still rising in younger men, leading to higher awareness of the disease. As the prostate gland enlarges and the prostate spasms, the prostate gland becomes more sensitive to changes in hormone levels and the urinary retention of natural prostatic stimulants and prostate-specific antigen (PSA). This is the reason why the prostate is more susceptible to the effects of prostatic hyperplasia (BPH) than the prostate of men with normal prostate gland.
The progression of BPH has been linked to the development of prostate cancer.
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Finasteride is a medication commonly prescribed for conditions such as male pattern baldness, benign prostatic hyperplasia (BPH), and even prostate cancer. It works by inhibiting the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT). DHT is a hormone that causes symptoms in men, such as hair loss, an enlarged prostate, and difficulty urinating. Finasteride is also used to treat male pattern baldness by blocking the effects of DHT.
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Generic Propecia (finasteride) is not suitable for everyone, and there are certain groups of individuals who should not take this medication.
1. Women: Generic Propecia is intended for use in men only. Women who are pregnant, may become pregnant, or are breastfeeding should not handle crushed or broken Generic Propecia tablets due to the risk of absorption through the skin, which could potentially harm the developing fetus or nursing baby.
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Finasteride is a hormone antagonist which stops testosterone from being converted to dihydrotestosterone, the hormone that stimulates prostate growth. Finasteride can be used to help with signs related to benign prostatic hypertrophy such as increased urge to urinate, straining to defecate, and blood in the urine.
Finasteride blocks production of the body's male hormone, which causes prostate enlargement.
Finasteride for dogs is used in the treatment of benign prostatic hypertrophy (enlarged prostate) in dogs.
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If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.
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